Cold plasma therapy employs a low-temperature ionized gas to interact with skin tissues, promoting cellular signaling that accelerates wound healing and tissue regeneration. Clinically, it reduces microbial load, manages inflammation, and stimulates collagen and elastin synthesis while minimizing thermal damage. Applications include acne scar revision, chronic wound care, and non-ablative skin rejuvenation across diverse skin types. Treatments are typically brief and performed in outpatient settings, often combined with topical agents for enhanced effect. Safety profiles report limited side effects when administered by trained clinicians.